Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017680 | 0.91 | RIPK1 (0.43) | RIPK1PDE5AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7100815 | 0.89 | RIPK1 (0.42) | RIPK1PDE5AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7101502 | 0.81 | CCNB2 (0.44) | RIPK1PDE5AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7014990 | 0.80 | RIPK1 (0.48) | RIPK1KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7009747 | 0.78 | CCNB2 (0.63) | RIPK1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL26087406 | 0.78 | KDM4E (0.68) | PDE5AKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7016833 | 0.78 | CCNB2 (0.42) | RIPK1KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6282533 | 0.77 | KDM4E (0.47) | RIPK1KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL5945897 | 0.76 | ERN1 (0.49) | KDM4ESMN1; SMN2ALDH1A1RAB9AMAPT | |
| SCHEMBL7096737 | 0.73 | NPY5R (0.45) | RIPK1KDM4ESMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294718-A2 | 6,5-FUSED BICYCLIC HETEROCYCLES | WARNER-LAMBERT COMPANY LLC (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096336-A2 | 6,5-FUSED BICYCLIC HETEROCYCLES | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |