SCHEMBL7101270

SCHEMBL7101270

COc1cccc(Br)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.46
CA2 P00918 4/20 0.46
CA7 P43166 3/20 0.46
CA9 Q16790 3/20 0.46
CA12 O43570 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CA4 P22748 1/20 0.46
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
MAPT P10636 3/20 0.41
ALDH1A1 P00352 2/20 0.41
TP53 P04637 2/20 0.41
HPGD P15428 2/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
CYP3A4 P08684 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
MAPK1 P28482 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29588385 1.00 CA1 (0.46) CA1CA2CA7CA9CA12
SCHEMBL630768 0.83 CA1 (0.58) CA1CA2CA7CA9CA12
SCHEMBL19770514 0.82 TOP1 (0.44) CA1CA2CA7CA9CA12
SCHEMBL29532976 0.79 NQO2 (0.41) CA1CA2CA7CA9CA12
SCHEMBL1662632 0.79 NQO2 (0.41) CA1CA2CA7CA9CA12
SCHEMBL971122 0.78 CA1 (0.60) CA1CA2CA7CA9CA12
SCHEMBL16055919 0.78 PTPN1 (0.37) HTR2AHTR2CMAPTALDH1A1HPGD
SCHEMBL6873872 0.77 KDM1A (0.31)
SCHEMBL7105909 0.77 CA1 (0.46) CA1CA2CA7CA9CA12
SCHEMBL25384973 0.77 L3MBTL1 (0.46) MAPTALDH1A1HPGDKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110669014-B Preparation method of oxalagogri intermediate 重庆医药高等专科学校 2021-04-30 CN claimed
CN-110669014-A Preparation method of oxalagogri intermediate 重庆医药高等专科学校 2020-01-10 CN claimed
CN-108365264-A A kind of lithium battery tertiary electrolyte 湖南博信新能源科技有限公司 2018-08-03 CN claimed
CN-101020628-A Preparation method of 2, 4-difluoro-3-hydroxybenzoic acid CHEN WEIDONG (CN) 2007-08-22 CN claimed
US-20260028354-A1 TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS REGENT OF THE UNIV OF MICHIGAN (US) 2026-01-29 US disclosed
US-12421191-B2 3-hydroxyoxindole derivatives as CRHR2 antagonist RAQUALIA PHARMA INC. (JP) 2025-09-23 US disclosed
EP-4554948-A1 TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Regents of the University of Michigan (US) 2025-05-21 EP disclosed
WO-2025064567-A1 TRICYCLIC PHENOLS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2025-03-27 WO disclosed
WO-2025020191-A1 STEROID COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF 珂阑(上海)医药科技有限公司 2025-01-30 WO disclosed
WO-2025021193-A1 STEROID COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 珂阑(上海)医药科技有限公司 2025-01-30 WO disclosed
CN-111989321-B KRAS G12C inhibitors 米拉蒂治疗股份有限公司 2024-05-14 CN disclosed
US-20240101553-A1 KRAS G12C INHIBITORS MIRATI THERAPEUTICS INC (US) 2024-03-28 US disclosed
CN-1447797-A New process for preparing quinolone-carboxylic acid DALIAN LYNCHEM CO LTD (CN) 2003-10-08 CN disclosed
US-5223536-A Pyrethroid-like pesticides FMC CORPORATION (US) 1993-06-29 US disclosed
WO-1993001715-A1 1,4-DIARYL-1-CYCLOPROPYL-4-SUBSTITUTED BUTANES AS INSECTICIDES AND ACARICIDES FMC CORPORATION (US) 1993-02-04 WO disclosed
EP-0488861-A1 Process for the preparation of alkoxylated aromatic compounds RHONE-POULENC CHIMIE (FR) 1992-06-03 EP disclosed
EP-0455545-A1 Process for the preparation of mono- or polyalkoxylated aromatic compounds RHONE-POULENC CHIMIE (FR) 1991-11-06 EP disclosed
EP-0434517-A2 Process for the preparation of mono- or poly-alkoxylated aromatic compounds RHONE-POULENC CHIMIE (FR) 1991-06-26 EP disclosed
EP-0434516-A2 Process for the preparation of mono- or poly-alkoxylated aromatic compounds RHONE-POULENC CHIMIE (FR) 1991-06-26 EP disclosed
CN-87102455-A Diphenyl ether derivatives pesticide compound 1988-01-27 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028354-A1 TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ESRRA, ESR2, ESRRB CA1 1445/4885CA2 1166/4885CA7 629/4885
US-12421191-B2 3-hydroxyoxindole derivatives as CRHR2 antagonist CRHR2, CRHR1, CRH CA1 2346/4885CA2 1310/4885CA7 3480/4885
US-20240101553-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS CA1 3612/4885CA2 2065/4885CA7 2361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.