SCHEMBL7101373

SCHEMBL7101373

COc1cccc(C=CC(=O)c2cccc(N(C)C)c2)c1OC

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.66
PTPN1 P18031 2/20 0.65
RELA Q04206 3/20 0.65
LMNA P02545 2/20 0.65
ALDH1A1 P00352 1/20 0.65
NTSR1 P30989 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
ALOX5 P09917 1/20 0.62
NPC1 O15118 2/20 0.61
RAB9A P51151 2/20 0.61
TRPM8 Q7Z2W7 1/20 0.59
NFE2L2 Q16236 2/20 0.59
NR1H4 Q96RI1 1/20 0.57
CYP1A1 P04798 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
BCHE P06276 1/20 0.54
MAPT P10636 1/20 0.54
ABCB1 P08183 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7101969 0.90 NR1H4 (0.70) MAOBPTPN1RELALMNAALDH1A1
SCHEMBL7097737 0.88 ALOX5 (0.73) MAOBPTPN1RELALMNAALDH1A1
SCHEMBL4026900 0.83 LMNA (0.78) MAOBRELALMNAALDH1A1NTSR1
SCHEMBL7100872 0.82 MAOB (0.69) MAOBPTPN1RELALMNAALDH1A1
SCHEMBL28263081 0.82 RELA (0.73) MAOBRELALMNAALDH1A1NTSR1
SCHEMBL7096590 0.81 NPC1 (0.66) MAOBRELALMNAALDH1A1NTSR1
SCHEMBL28263080 0.80 SNCA (0.71) MAOBPTPN1RELALMNAALDH1A1
SCHEMBL31676388 0.78 ALOX5 (0.78) MAOBRELALMNAALDH1A1NTSR1
SCHEMBL6357635 0.78 ALOX5 (0.78) MAOBRELALMNAALDH1A1NTSR1
SCHEMBL6357636 0.78 ALOX5 (0.78) MAOBRELALMNAALDH1A1NTSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003097577-A1 CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME SYNTH'E163 (SOCIETE ANONYME) (FR) 2003-11-27 WO claimed