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Iopamidol

Iopamidol

SCHEMBL7101453

C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I.C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 1.00
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ CYP2C19 P33261 1/20 0.33
▸ HIF1A Q16665 1/20 0.33
▸ CYP3A4 P08684 1/20 0.30
▸ MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iopamidol SCHEMBL471484 1.00 LMNA (1.00) LMNASMN1; SMN2CYP2C19HIF1ACYP3A4
Iopamidol SCHEMBL27781 1.00 LMNA (1.00) LMNASMN1; SMN2CYP2C19HIF1ACYP3A4
SCHEMBL22006124 0.96 LMNA (0.92) LMNASMN1; SMN2CYP2C19HIF1A
Iopamidol SCHEMBL3424448 0.96 LMNA (0.92) LMNASMN1; SMN2CYP2C19HIF1A
Iopamidol SCHEMBL2140144 0.96 LMNA (0.92) LMNASMN1; SMN2CYP2C19HIF1ACYP3A4
SCHEMBL31409203 0.95 LMNA (0.90) LMNASMN1; SMN2CYP2C19HIF1ACYP3A4
SCHEMBL7709204 0.95 LMNA (0.90) LMNASMN1; SMN2CYP2C19HIF1A
SCHEMBL13283626 0.95 LMNA (0.90) LMNASMN1; SMN2CYP2C19HIF1A
SCHEMBL22661225 0.92 LMNA (0.85) LMNASMN1; SMN2CYP2C19HIF1A
SCHEMBL15297031 0.92 LMNA (0.84) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106255503-A For delivering the compositions of anticancer agent 法国加柏公司 2016-12-21 — — CN disclosed
EP-1337505-A1 A PROCESS FOR THE PREPARATION OF N,N'-SUBSTITUTED 5-AMINO-1,3-BENZENEDICARBOXAMIDES Bracco Imaging S.p.A. (IT) 2003-08-27 — — EP disclosed
WO-2002044125-A1 A PROCESS FOR THE PREPARATION OF N,N'-SUBSTITUTED 5-AMINO-1,3-BENZENEDICARBOXAMIDES BRACCO IMAGING S.P.A. (IT) 2002-06-06 — — WO disclosed