Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019518 | 0.78 | GRM2 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7018582 | 0.73 | HCRTR2 (0.36) | PTGS1PTGS2PTGDR2MEN1KMT2A | |
| SCHEMBL7103681 | 0.71 | LMNA (0.35) | ALDH1A1PPARGPTGS2PTGDR2LMNA | |
| SCHEMBL7103549 | 0.70 | PTPN7 (0.35) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7100609 | 0.70 | CYP11B1 (0.31) | PTGS2 | |
| SCHEMBL7167937 | 0.70 | TSHR (0.42) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7021904 | 0.68 | CYP1A2 (0.38) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6406400 | 0.67 | LTB4R (0.37) | ACHEALDH1A1LTB4RLTB4R2PTGS1 | |
| SCHEMBL6405304 | 0.67 | LTB4R (0.37) | ACHEALDH1A1LTB4RLTB4R2PTGS1 | |
| SCHEMBL9535853 | 0.66 | AKR1B1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | claimed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | claimed |
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |