Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 2/20 | 0.35 |
| ▸ | CAT | P04040 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.31 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100107 | 0.82 | MAPT (0.34) | PTPN7MEN1KMT2AHSPA1AHSPA8 | |
| SCHEMBL7021904 | 0.80 | CYP1A2 (0.38) | MEN1KMT2AALDH1A1CYP19A1TSHR | |
| SCHEMBL7019518 | 0.79 | GRM2 (0.36) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL7101699 | 0.70 | ACHE (0.35) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL27818780 | 0.68 | POLB (0.35) | PTPN7CATMEN1KMT2AALDH1A1 | |
| SCHEMBL7103681 | 0.67 | LMNA (0.35) | ALDH1A1TSHR | |
| SCHEMBL7018582 | 0.67 | HCRTR2 (0.36) | MEN1KMT2A | |
| SCHEMBL7100609 | 0.66 | CYP11B1 (0.31) | — | |
| SCHEMBL9465746 | 0.65 | ALDH1A1 (0.44) | PTPN7TRPM8ALDH1A1POLB | |
| SCHEMBL8815600 | 0.65 | PTPN7 (0.38) | PTPN7NR3C1CYP19A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |