Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018582 | 0.88 | HCRTR2 (0.36) | PTGDR2PTGS2 | |
| SCHEMBL7108605 | 0.78 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL7019518 | 0.77 | GRM2 (0.36) | ALDH1A1 | |
| SCHEMBL7100609 | 0.77 | CYP11B1 (0.31) | PTGS2 | |
| SCHEMBL7100181 | 0.74 | PTGS1 (0.41) | PTGDR2PTGS2 | |
| SCHEMBL7021505 | 0.73 | LMNA (0.36) | LMNAMAPTTSHRMAPK1HTT | |
| SCHEMBL7101699 | 0.71 | ACHE (0.35) | LMNAPTGDR2ALDH1A1PTGS2PPARG | |
| SCHEMBL7171935 | 0.71 | SMN1; SMN2 (0.47) | LMNATSHRMAPK1 | |
| SCHEMBL7022958 | 0.69 | GAA (0.47) | LMNAMAPTMAPK1HTTALDH1A1 | |
| SCHEMBL7174724 | 0.69 | ALDH1A1 (0.49) | LMNAMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |