Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724725 | 0.83 | MAPT (0.45) | MAPTGAARECQLALDH1A1HPGD | |
| SCHEMBL6733097 | 0.82 | MAPT (0.47) | MAPTKMT2AGAAMEN1LMNA | |
| SCHEMBL7103032 | 0.81 | TRPC5 (0.37) | POLBMAPTKMT2AGAAMEN1 | |
| SCHEMBL7035440 | 0.74 | KDM4E (0.40) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL6256590 | 0.73 | TP53 (0.47) | CMA1PARGLMNAMMP1MMP13 | |
| SCHEMBL7105942 | 0.73 | ADORA2B (0.48) | POLBMAPTKMT2AGAAMEN1 | |
| SCHEMBL6254110 | 0.71 | TRPA1 (0.48) | KMT2AMEN1CYP3A4LMNAALDH1A1 | |
| SCHEMBL6255213 | 0.71 | MAPT (0.50) | MAPTLMNAALDH1A1HPGD | |
| SCHEMBL7038274 | 0.70 | HDAC1 (0.50) | POLBMAPTCMA1LMNAALDH1A1 | |
| SCHEMBL6236463 | 0.70 | MMP13 (0.40) | MAPTKMT2AGAAMEN1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |