Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236463 | 0.86 | MMP13 (0.40) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL6233542 | 0.81 | MAPT (0.56) | ALDH1A1MAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL7103030 | 0.81 | POLB (0.42) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL6239791 | 0.79 | MAPT (0.48) | ALDH1A1GAAMAPTLMNAHPGD | |
| SCHEMBL7018890 | 0.78 | TRPA1 (0.52) | ALDH1A1HSP90AA1GAAKMT2AATM | |
| SCHEMBL7021108 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL7035440 | 0.76 | KDM4E (0.40) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6254110 | 0.75 | TRPA1 (0.48) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL7105942 | 0.75 | ADORA2B (0.48) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL7105492 | 0.74 | HDAC8 (0.47) | ALDH1A1GAAPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |