Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 5/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.47 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.47 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.47 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869579 | 0.88 | KDM4E (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2BACE1 | |
| SCHEMBL5177689 | 0.78 | KDM4E (0.73) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL19244312 | 0.78 | KDM4E (0.73) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL1614877 | 0.78 | KDM4E (0.73) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL5151387 | 0.77 | MAPT (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2BACE1 | |
| SCHEMBL5151394 | 0.77 | MAPT (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2BACE1 | |
| SCHEMBL466048 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL4629237 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL4421062 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 | |
| SCHEMBL8872479 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1HPGDSMN1; SMN2AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339665-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | Nicox S.A. (FR) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002030866-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX S.A. (FR) | 2002-04-18 | — | — | WO | disclosed |