Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106096 | 0.89 | ERCC1 (0.42) | MMP1MMP2MMP9OPRD1OPRK1 | |
| SCHEMBL7103454 | 0.81 | HTR7 (0.46) | OPRD1OPRK1OPRM1HTR7CYP3A4 | |
| SCHEMBL7103181 | 0.78 | CYP3A4 (0.45) | NR1H2NR1H3MMP1MMP2MMP9 | |
| SCHEMBL7103185 | 0.71 | OPRK1 (0.54) | NR1H2NR1H3MMP1MMP2MMP9 | |
| SCHEMBL19552539 | 0.70 | KMT2A (0.43) | OPRM1CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19552415 | 0.69 | KMT2A (0.42) | OPRM1CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL7442260 | 0.69 | CYP2C19 (0.55) | MMP1MMP2CYP3A4CYP2C19TACR1 | |
| SCHEMBL31697580 | 0.67 | NPC1 (0.51) | CYP3A4CYP2C19ESRRGNPC1ALDH1A1 | |
| SCHEMBL7106093 | 0.67 | ERCC1 (0.48) | MMP1MMP2MMP9CYP2C19NPC1 | |
| SCHEMBL28863035 | 0.66 | EPHX1 (0.56) | MMP1MMP2CYP3A4CYP2C19TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |