Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103181 | 0.90 | CYP3A4 (0.45) | ERCC1ERCC4MMP1MMP2MMP9 | |
| SCHEMBL7106096 | 0.77 | ERCC1 (0.42) | ERCC1ERCC4MMP1MMP2MMP9 | |
| SCHEMBL11230906 | 0.75 | ADRB2 (0.44) | ERCC1ERCC4HIF1ANPC1RAB9A | |
| SCHEMBL20509339 | 0.73 | MMP8 (0.52) | ERCC1ERCC4MMP1MMP2MMP9 | |
| SCHEMBL30267678 | 0.73 | MMP8 (0.52) | ERCC1ERCC4MMP1MMP2MMP9 | |
| SCHEMBL4388189 | 0.72 | ERCC1 (0.53) | ERCC1ERCC4MMP8HPGDEPHX1 | |
| SCHEMBL7106098 | 0.70 | OPRK1 (0.53) | ERCC1ERCC4MMP1MMP2MMP9 | |
| SCHEMBL7435493 | 0.70 | MMP8 (0.57) | ERCC1ERCC4MMP8HPGDEPHX1 | |
| SCHEMBL16839634 | 0.70 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2806074 | 0.70 | CYP1A2 (0.59) | MMP1SLC2A4MMP2MMP9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |