Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | GLI2 | P10070 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106098 | 0.89 | OPRK1 (0.53) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7103456 | 0.81 | OPRK1 (0.42) | OPRK1OPRD1LMNA | |
| SCHEMBL13066398 | 0.73 | KMT2A (0.56) | POLBCYP2C19 | |
| SCHEMBL7103181 | 0.71 | CYP3A4 (0.45) | OPRK1OPRD1NR1H2NR1H3MMP1 | |
| SCHEMBL7103182 | 0.71 | NR1H2 (0.43) | OPRK1OPRD1NR1H2NR1H3OPRM1 | |
| SCHEMBL7106355 | 0.70 | OPRK1 (1.00) | OPRK1OPRD1GLI1GLI2OPRM1 | |
| SCHEMBL7442260 | 0.69 | CYP2C19 (0.55) | MMP1MMP2CYP3A4CYP2C19TACR1 | |
| SCHEMBL5357017 | 0.69 | MTNR1A (0.54) | — | |
| SCHEMBL31697580 | 0.67 | NPC1 (0.51) | POLBCYP3A4CYP2C19 | |
| SCHEMBL28863035 | 0.66 | EPHX1 (0.56) | MMP1MMP2CYP3A4CYP2C19TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |