SCHEMBL7104697

SCHEMBL7104697

Cc1ccc(C(c2ccccc2)N(C(=O)OCc2ccccc2Cl)C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
CTSK P43235 4/20 0.39
JAK3 P52333 1/20 0.37
BTK Q06187 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37
CTSS P25774 1/20 0.35
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8080769 0.79 TLR2 (0.45) CTSKJAK3BTK
Lysine SCHEMBL11590831 0.76 ALDH1A1 (0.42) ALDH1A1TSHRCTSKCYP1A2CYP3A4
SCHEMBL7993210 0.75 TPSAB1 (0.43) ALDH1A1CTSKCYP1A2CYP3A4CYP2D6
SCHEMBL8297502 0.75 TPSAB1 (0.43) ALDH1A1CTSKCYP1A2CYP3A4CYP2D6
SCHEMBL29280233 0.75 TPSAB1 (0.43) ALDH1A1CTSKCYP1A2CYP3A4CYP2D6
Lysine SCHEMBL11725815 0.73 CPB1 (0.48) ALDH1A1TSHR
SCHEMBL972564 0.72 CTSK (0.47) CTSKJAK3BTKCTSS
SCHEMBL31192697 0.71 CYP1A2 (0.51) CYP1A2CYP3A4CYP2D6CYP2C9HPGD
SCHEMBL5497442 0.71 CYP1A2 (0.51) CYP1A2CYP3A4CYP2D6CYP2C9HPGD
SCHEMBL1938311 0.71 CYP1A2 (0.51) CYP1A2CYP3A4CYP2D6CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004001055-A2 PNA PRODRUGS SANTARIS PHARMA A/S (DK) 2003-12-31 WO disclosed