Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 7/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710045 | 0.88 | PDE7A (0.41) | ABCC9ABCC8KCNJ11KCNJ8SLC6A2 | |
| SCHEMBL915401 | 0.87 | HDAC10 (0.37) | ACSS2RORCMEN1ALDH1A1KMT2A | |
| SCHEMBL711220 | 0.87 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8SLC6A2 | |
| SCHEMBL3258358 | 0.87 | LMNA (0.41) | SLC6A2SLC6A4SLC6A3LMNATP53 | |
| SCHEMBL916416 | 0.87 | GNRHR (0.39) | ACSS2GNRHRLMNAMAPTRORC | |
| SCHEMBL710137 | 0.86 | ALDH1A1 (0.39) | SLC6A2SLC6A4SLC6A3LMNATP53 | |
| SCHEMBL917717 | 0.86 | SMN1; SMN2 (0.32) | ABCC9ABCC8KCNJ11KCNJ8SLC6A2 | |
| SCHEMBL916474 | 0.85 | IMPDH2 (0.40) | ACSS2LMNAMAPTRORCMEN1 | |
| SCHEMBL3256709 | 0.85 | LMNA (0.37) | ABCC9ABCC8KCNJ11KCNJ8SLC6A2 | |
| SCHEMBL916206 | 0.85 | GNRHR (0.39) | ABCC9ABCC8KCNJ11KCNJ8ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124647-B2 | Non-steroidal androgens compounds | N.V. ORGANON (NL) | 2012-02-28 | — | — | US | disclosed |
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | MERCK SHARP & DOHME B.V. (NL) | 2011-03-17 | — | — | US | disclosed |
| US-20110009428-A1 | NOVEL ANDROGENS | N.V. ORGANON (NL) | 2011-01-13 | — | — | US | disclosed |
| US-7812036-B2 | Androgens | N.V. ORGANON (NL) | 2010-10-12 | — | — | US | disclosed |
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| EP-1742912-B1 | NOVEL ANDROGENS | ORGANON NV (NL) | 2010-08-25 | — | — | EP | disclosed |
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |
| US-20070225352-A1 | Novel Androgens | PHARMACOPELA DRUG DISCOVERY, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AKZO NOBEL N.V. (NL) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225352-A1 | Novel Androgens | NR5A1, AR, SHBG | ABCC9 2994/4885ABCC8 2544/4885KCNJ11 2886/4885 |
| US-20110065768-A1 | NON-STEROIDAL ANDROGENS COMPOUNDS | AR, NR5A1, SHBG | ABCC9 2067/4885ABCC8 1553/4885KCNJ11 3473/4885 |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AR, NR5A1, SHBG | ABCC9 3868/4885ABCC8 2991/4885KCNJ11 3232/4885 |
| US-20110009428-A1 | NOVEL ANDROGENS | NR5A1, AR, NR3C2 | ABCC9 1793/4885ABCC8 1404/4885KCNJ11 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.