Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.59 |
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504642 | 0.84 | MEN1 (0.83) | SGMS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28661611 | 0.83 | SGMS2 (0.68) | SGMS2PKMMEN1KMT2AMAPT | |
| SCHEMBL875474 | 0.83 | SGMS2 (1.00) | SGMS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5431925 | 0.82 | L3MBTL1 (0.57) | SGMS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9856969 | 0.81 | ALDH1A1 (0.58) | SGMS2PKMMEN1KMT2AMAPT | |
| SCHEMBL11243891 | 0.80 | MEN1 (0.50) | SGMS2PKMMEN1KMT2AMAPT | |
| SCHEMBL5491897 | 0.80 | LIG1 (0.71) | SGMS2PKMMEN1KMT2AMAPT | |
| SCHEMBL4006491 | 0.80 | LMNA (0.64) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL5049435 | 0.80 | SGMS2 (0.64) | SGMS2MEN1KMT2AMAPTLMNA | |
| SCHEMBL17551891 | 0.79 | SGMS2 (0.74) | SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013639-B1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | HOFFMANN LA ROCHE (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6335459-B1 | PROSTAGLANDIN I2 RECEPTOR MODULATORS; TREATING TISSUE NECROSIS, PREMATURE UTERINE CONTRACTION, GASTRIC ULCERATION, SEXUAL DYSFUNCTION, MENSTRUAL PAIN AND IMPROPER WOUND HEALING, IMMUNOREGULATION, PLATELET AGGREGATION OR NEUTROPHIL FUNCTION | SYNTEX (U.S.A.) LLC | 2002-01-01 | — | — | US | disclosed |
| EP-1013639-A1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |