Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.49 |
| ▸ | RELA | Q04206 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100142 | 0.87 | SIGMAR1 (0.55) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL6768621 | 0.84 | NPC1 (0.68) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL6765702 | 0.84 | SIGMAR1 (0.51) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL6775299 | 0.83 | SIGMAR1 (0.50) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| Hydrochloric Acid SCHEMBL6775006 | 0.82 | NPC1 (0.66) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL6774950 | 0.82 | SIGMAR1 (0.55) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| Hydrochloric Acid SCHEMBL6769759 | 0.81 | SIGMAR1 (0.54) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL7103364 | 0.80 | TAS1R3 (0.53) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL6775199 | 0.80 | RAB9A (0.54) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL7099371 | 0.78 | NPC1 (0.73) | SIGMAR1NPC1RAB9ASMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030153763-A1 | Pharmaceutically active compounds and methods of use | WYETH | 2003-08-14 | — | — | US | claimed |
| US-20020099084-A1 | Pharmaceutically active compounds and methods of use | WYETH | 2002-07-25 | — | — | US | claimed |
| US-6358993-B1 | TREATMENT OF NEUROLOGICAL INJURY AND NEURODEGENERATIVE DISORDERS; NEUROPROTECTIVE AGENTS; SUBSTITUTED INDOLINYL AND INDOLINYL GUANIDINE DERIVATIVES | CENES PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153763-A1 | Pharmaceutically active compounds and methods of use | ACHE, PARK7, NLN | SIGMAR1 2813/4885NPC1 246/4885RAB9A 1903/4885 |
| US-20020099084-A1 | Pharmaceutically active compounds and methods of use | ACHE, PARK7, NLN | SIGMAR1 2813/4885NPC1 246/4885RAB9A 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.