Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 3/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3286475 | 0.85 | TDP1 (0.42) | TDP1L3MBTL1NR1H4ALDH1A1HSD17B10 | |
| SCHEMBL8742181 | 0.75 | VNN1 (0.36) | TDP1L3MBTL1NR1H4ALDH1A1LMNA | |
| SCHEMBL2421674 | 0.73 | KCNH2 (0.40) | ALDH1A1HSD17B10HPGDESRRGLMNA | |
| SCHEMBL24860061 | 0.69 | NR1H4 (0.55) | NR1H4FAAHESRRGLMNAESRRB | |
| SCHEMBL11401981 | 0.69 | NR1H4 (0.57) | NR1H4HSD17B10ESRRGLMNAESRRB | |
| SCHEMBL3281085 | 0.68 | L3MBTL1 (0.44) | TDP1L3MBTL1NR1H4ALDH1A1HPGD | |
| SCHEMBL26864193 | 0.66 | MAOB (0.46) | TDP1ALDH1A1ESRRGKCNH2 | |
| SCHEMBL3284037 | 0.66 | FNTA (0.32) | — | |
| SCHEMBL19971105 | 0.65 | SIGMAR1 (0.45) | L3MBTL1HDAC1HDAC8HDAC3MAPK1 | |
| SCHEMBL3283849 | 0.65 | TDP1 (0.46) | TDP1L3MBTL1NR1H4SLC13A5ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030078239-A1 | Ketone compounds and compositions for cholesterol management and related uses | ESPERION THERAPEUTICS, INC. | 2003-04-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078239-A1 | Ketone compounds and compositions for cholesterol management and related uses | PC, HMGCR, GPR119 | TDP1 1892/4885L3MBTL1 3242/4885NR1H4 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.