Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.33 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106497 | 0.98 | CYP1A2 (0.44) | CYP1A2CYP2D6CYP2C19LMNANPC1 | |
| Hydrochloric Acid SCHEMBL8730207 | 0.80 | TP53 (0.42) | SMN1; SMN2MAPK1L3MBTL1TP53 | |
| SCHEMBL8757226 | 0.80 | SIGMAR1 (0.34) | CYP1A2CYP2D6CYP2C19LMNANPC1 | |
| Hydrochloric Acid SCHEMBL392362 | 0.79 | ESR1 (0.58) | LMNAESR1ADRA2AADORA3TACR2 | |
| SCHEMBL4237394 | 0.78 | TP53 (0.42) | SMN1; SMN2MAPK1TP53 | |
| Hydrochloric Acid SCHEMBL391947 | 0.77 | LMNA (0.46) | CYP1A2CYP2D6CYP2C19LMNANPC1 | |
| Hydrochloric Acid SCHEMBL9343453 | 0.76 | MEN1 (0.46) | SMN1; SMN2MAPK1TP53 | |
| SCHEMBL9120855 | 0.74 | TP53 (0.42) | SMN1; SMN2MAPK1TP53 | |
| Water SCHEMBL9247303 | 0.72 | DNM1 (0.43) | SMN1; SMN2MAPK1TP53 | |
| SCHEMBL8757335 | 0.71 | DNM1 (0.46) | SMN1; SMN2MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974595-B1 | PROCESS FOR PRODUCING BORON COMPOUNDS | SHOWA DENKO KK (JP) | 2003-10-01 | — | — | EP | disclosed |
| EP-0922708-B1 | Production method of borate compounds | SHOWA DENKO KK (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6140537-A | REACTING AN ORGANIC OXYBORON COMPOUND WITH LITHIUM, MAGNESIUM, OR COMPOUND THEREOF; FORMING BORON ANION COMPOUND; ION EXCHANGING | SHOWA DENKO K.K. (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0974595-A1 | PROCESS FOR PRODUCING BORON COMPOUNDS | Showa Denko Kabushiki Kaisha (JP) | 2000-01-26 | — | — | EP | disclosed |
| US-6002044-A | REACTING A LITHIUM OR MAGNEISIUM, A HALIDE AND A BORONATE PRECURSOR OBTAINED IN A FIRSST SIMILAR STEP USING A BORIDE; ADDING AN ONIIUM HALIDE TO THE METAL BORATE; PURITY | SHOWA DENKO K.K. (JP) | 1999-12-14 | — | — | US | disclosed |
| EP-0922708-A2 | Production method of borate compounds | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1999-06-16 | — | — | EP | disclosed |