Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655302 | 0.84 | CNR2 (0.50) | LMNAPOLBALDH1A1HPGDP2RX7 | |
| SCHEMBL7654531 | 0.83 | LMNA (0.47) | LMNAPOLBALDH1A1HPGDP2RX7 | |
| SCHEMBL7108548 | 0.82 | SCN10A (0.37) | LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL18157911 | 0.80 | KMT2A (0.61) | LMNAPOLBALDH1A1HPGDP2RX7 | |
| SCHEMBL7104694 | 0.78 | HPGD (0.37) | LMNAPOLBALDH1A1HPGD | |
| SCHEMBL7654754 | 0.77 | LMNA (0.66) | LMNAPOLBALDH1A1HPGDP2RX7 | |
| SCHEMBL12194924 | 0.75 | KDM4E (0.55) | LMNAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL31432073 | 0.75 | KDM4E (0.55) | LMNAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL7107812 | 0.74 | POLB (0.47) | LMNAPOLBP2RX7KDM4EALOX15 | |
| SCHEMBL7661497 | 0.73 | ALDH1A1 (0.46) | LMNAPOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |