Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661155 | 0.85 | CHRNB2 (0.38) | ALDH1A1POLBMEN1KMT2ADNM1 | |
| SCHEMBL7659642 | 0.84 | PNP (0.39) | ALDH1A1POLBMEN1KMT2ACHRNB2 | |
| SCHEMBL7663487 | 0.82 | PNP (0.34) | ALDH1A1MAPK1 | |
| SCHEMBL7108601 | 0.79 | TYMP (0.39) | ALDH1A1TYMPPOLBMEN1KMT2A | |
| SCHEMBL17824014 | 0.75 | DNM1 (0.59) | ALDH1A1MEN1KMT2ADNM1AGER | |
| SCHEMBL17823521 | 0.75 | DNM1 (0.59) | ALDH1A1MEN1KMT2ADNM1AGER | |
| SCHEMBL7108600 | 0.75 | TYMP (0.41) | ALDH1A1TYMPPOLBMEN1KMT2A | |
| SCHEMBL721952 | 0.75 | DNM1 (0.59) | ALDH1A1MEN1KMT2ADNM1AGER | |
| SCHEMBL7658936 | 0.74 | KMT2A (0.45) | ALDH1A1TYMPPOLBMEN1KMT2A | |
| SCHEMBL7662648 | 0.74 | HSD17B10 (0.41) | POLBCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |