Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117287 | 1.00 | L3MBTL1 (0.45) | L3MBTL1TDP1CTDSP1MTNR1AMTNR1B | |
| SCHEMBL9379902 | 0.84 | MTNR1A (0.45) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL7314503 | 0.83 | TDP1 (0.56) | L3MBTL1TDP1CTDSP1MTNR1AMTNR1B | |
| SCHEMBL9040773 | 0.83 | MTNR1A (0.43) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL5695475 | 0.81 | CYP4F2 (0.45) | L3MBTL1TDP1MAPTCYP2C9ALOX15 | |
| SCHEMBL7867727 | 0.81 | CYP4F2 (0.45) | L3MBTL1TDP1MAPTCYP2C9ALOX15 | |
| SCHEMBL6496701 | 0.78 | CHRM2 (0.47) | MTNR1AMTNR1BPIN1DRD2DRD4 | |
| SCHEMBL6627932 | 0.78 | CHRM2 (0.47) | MTNR1AMTNR1BPIN1DRD2DRD4 | |
| SCHEMBL7557806 | 0.76 | LTB4R (0.47) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 | |
| SCHEMBL7552940 | 0.76 | LTB4R (0.47) | MTNR1AMTNR1BMAPTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353670-A2 | USE OF CHROMANES | Bayer Aktiengesellschaft (DE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002055078-A2 | USE OF CHROMANES FOR TREATING PARKINSON'S DISEASE | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-18 | — | — | WO | disclosed |
| EP-0540914-B1 | 2-Aminomethylchromans as active ingredients in medicaments for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0539803-B1 | Triazospirodecanone-methyl-chromans for the treatment of central nervous system illnesses | BAYER AG (DE) | 1999-01-07 | — | — | EP | disclosed |
| EP-0546389-B1 | Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1996-04-17 | — | — | EP | disclosed |
| EP-0546388-B1 | Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1996-03-27 | — | — | EP | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| EP-0546389-A1 | Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0546388-A1 | Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0540914-A1 | 2-Aminomethylchromans as active ingredients in medicaments for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-05-12 | — | — | EP | disclosed |
| EP-0539803-A1 | Triazospirodecanone-methyl-chromans for the treatment of central nervous system illnesses | BAYER AG (DE) | 1993-05-05 | — | — | EP | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |