Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106490 | 0.81 | MEN1 (0.36) | LMNANTRK1PDE10A | |
| SCHEMBL7105165 | 0.78 | MAP2K1 (0.41) | LMNACYP2C19HIF1ASMOPDE9A | |
| SCHEMBL7106667 | 0.72 | KCNA5 (0.31) | — | |
| SCHEMBL7105124 | 0.72 | L3MBTL1 (0.41) | — | |
| SCHEMBL18230701 | 0.72 | SIRT6 (0.42) | SMOPDE9ACNR2MAP2K1ICAM1 | |
| SCHEMBL7109322 | 0.71 | SMO (0.39) | SMOPDE9ACNR2MAP2K1ICAM1 | |
| SCHEMBL7109193 | 0.71 | ICAM1 (0.40) | SMOPDE9ACNR2MAP2K1ICAM1 | |
| SCHEMBL7108875 | 0.70 | CYP2C19 (0.31) | CYP2C19HIF1ASMOCNR2MAP2K1 | |
| SCHEMBL7108522 | 0.69 | SMO (0.40) | SMO | |
| SCHEMBL7107240 | 0.69 | MEN1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |