Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.57 |
| ▸ | VCP | P55072 | 1/20 | 0.57 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.57 |
| ▸ | CTRC | Q99895 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 7/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | EIF4E | P06730 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23742640 | 0.86 | ABL1 (0.61) | ALOX5VCPCTRB1CTRCABL1 | |
| SCHEMBL23742655 | 0.81 | ABL1 (0.59) | ALOX5VCPCTRB1CTRCABL1 | |
| SCHEMBL7113187 | 0.79 | ALOX5 (0.65) | ALOX5VCPABL1CFTRMEN1 | |
| SCHEMBL205448 | 0.78 | ALOX5 (0.65) | ALOX5VCPCFTRMEN1KMT2A | |
| SCHEMBL205976 | 0.77 | ALOX5 (0.80) | ALOX5VCPABL1CFTRMEN1 | |
| SCHEMBL25959255 | 0.76 | ABL1 (0.57) | ALOX5VCPCTRB1CTRCABL1 | |
| SCHEMBL1694253 | 0.74 | ABL1 (0.63) | ALOX5VCPABL1CFTRMEN1 | |
| SCHEMBL204816 | 0.74 | ALOX5 (0.66) | ALOX5VCPMEN1KMT2ANPY5R | |
| SCHEMBL9645864 | 0.74 | NPC1 (0.69) | ALOX5VCPABL1CFTRKDM4E | |
| SCHEMBL23742653 | 0.74 | ALOX5 (0.71) | ALOX5VCPMEN1KMT2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | claimed |
| US-6586453-B2 | Useful in prophylaxis or treatment of thrombosis, angina, pectoris, cerebral infarction, myocardial/pulmonary infarction, intra-atrial thrombus in atrial fibrillation, diabetic complications, restenosis, and stroke | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-07-01 | — | — | US | claimed |
| US-20010044545-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2001-11-22 | — | — | US | claimed |
| WO-2001074793-A2 | SUBSTITUTED THIAZOLES AND THE USE THEREOF AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-10-11 | — | — | WO | claimed |
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | disclosed |
| US-6586453-B2 | Useful in prophylaxis or treatment of thrombosis, angina, pectoris, cerebral infarction, myocardial/pulmonary infarction, intra-atrial thrombus in atrial fibrillation, diabetic complications, restenosis, and stroke | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-07-01 | — | — | US | disclosed |
| US-20010044545-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044545-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | ALOX5 2040/4885VCP 2778/4885CTRB1 155/4885 |
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | ALOX5 2040/4885VCP 2778/4885CTRB1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.