Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922001 | 0.81 | AURKA (0.64) | AURKADHFRLMNATSHRALDH1A1 | |
| SCHEMBL6693457 | 0.80 | LMNA (0.45) | LMNAALDH1A1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL332569 | 0.78 | TSHR (0.70) | AURKADHFRLMNATSHRALDH1A1 | |
| SCHEMBL6312978 | 0.77 | ALDH1A1 (0.57) | LMNAALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL11313543 | 0.76 | CA1 (0.35) | LMNATSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL4850048 | 0.76 | KEAP1 (0.66) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL6688039 | 0.73 | KMT2A (0.34) | AURKADHFRLMNATSHRALDH1A1 | |
| SCHEMBL17593233 | 0.73 | ALDH1A1 (0.50) | AURKADHFRLMNATSHRALDH1A1 | |
| SCHEMBL1043396 | 0.73 | SMN1; SMN2 (0.45) | LMNAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28435387 | 0.73 | MEN1 (0.38) | ALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140871-A4 | THROMBIN OR FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1140871-A1 | THROMBIN OR FACTOR XA INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039108-A1 | THROMBIN OR FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |