Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158988 | 0.78 | PSIP1 (0.50) | KMT2ASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6693457 | 0.76 | LMNA (0.45) | KMT2ASMN1; SMN2LMNAALDH1A1PKM | |
| SCHEMBL160580 | 0.74 | PSIP1 (0.56) | KMT2ASMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL7112959 | 0.73 | AURKA (0.54) | KMT2ASMN1; SMN2AURKADHFRLMNA | |
| SCHEMBL28206252 | 0.73 | PSIP1 (0.34) | KMT2ASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9572295 | 0.72 | HSD11B1 (0.35) | SMN1; SMN2TSHRMAPT | |
| SCHEMBL4524280 | 0.70 | CA2 (0.47) | ALDH1A1MAPTPOLB | |
| SCHEMBL7863515 | 0.70 | HSD11B1 (0.33) | ALDH1A1HSD17B10 | |
| SCHEMBL28640869 | 0.70 | HTR6 (0.33) | — | |
| SCHEMBL8435774 | 0.70 | PSIP1 (0.41) | KMT2AALDH1A1MAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140871-A4 | THROMBIN OR FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-1140871-A1 | THROMBIN OR FACTOR XA INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039108-A1 | THROMBIN OR FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |