Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.41 |
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.42 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP3 | Q9H4L4 | 1/20 | 0.42 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL1739275 | 1.00 | MYC (0.52) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL8126703 | 1.00 | MYC (0.52) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL29811409 | 1.00 | MYC (0.52) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL3917281 | 1.00 | MYC (0.52) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL6305544 | 0.98 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL28847082 | 0.98 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL12984164 | 0.98 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| Water SCHEMBL11621674 | 0.98 | MYC (0.50) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL29392580 | 0.98 | MYC (0.53) | MYCRAPGEF4SUMO2SUMO1SENP7 | |
| SCHEMBL1748 | 0.98 | MYC (0.53) | MYCRAPGEF4SUMO2SUMO1SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5387 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025262596-A1 | METHODS OF MAKING OSIVELOTOR | PFIZER INC. (US) | 2025-12-26 | — | — | WO | claimed |
| WO-2025049963-A2 | COMPOSITIONS AND METHODS FOR THE PREPARATION OF PURIFIED CANNABINOL AND HEXAHYDROCANNABINOL AND THEIR ACETATE DERIVATIVES | JONESING LABS, LLC (US) | 2025-03-06 | — | — | WO | claimed |
| CN-115894522-B | Synthesis method and application of molecule containing triazole penicillin | 海南医学院 | 2024-10-22 | — | — | CN | claimed |
| CN-118652243-A | Peroxisome proliferator-activated receptor (PPARs) agonist, preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-09-17 | — | — | CN | claimed |
| CN-118307559-A | Preparation method of toluenesulfonic acid Ai Duosha class-A monohydrate | 重庆普佑生物医药有限公司 | 2024-07-09 | — | — | CN | claimed |
| CN-117551114-A | Preparation method of tosylate Ai Duosha class-A monohydrate | 康普药业股份有限公司 | 2024-02-13 | — | — | CN | claimed |
| WO-2024018395-A1 | METHODS AND INTERMEDIATES FOR PREPARING 2-[(4-{6-[(4-CYANO-2-FLUOROBENZYL)OXY]PYRIDIN-2-YL}PIPERIDIN-1-YL)METHYL]-1-[(2S)-OXETAN-2-YLMETHYL]-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID, 1,3-DIHYDROXY-2-(HYDROXYMETHYL)PROPAN-2-AMINE SALT | PFIZER INC. (US) | 2024-01-25 | — | — | WO | claimed |
| CN-115073455-B | Preparation method and application of fluorine substituted perylene imide derivative | 北京化工大学 | 2023-12-15 | — | — | CN | claimed |
| WO-2023187480-A1 | COLORIMETRIC SYSTEM FOR DETECTION OF COVID-19 USING EXHALED BREATH METABOLITES | BAGHERI HASAN (IR) | 2023-10-05 | — | — | WO | claimed |
| EP-3986867-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 2-(2,6-DICHLOROPHENYL)-1-[(1S,3R)-3-(HYDROXYMETHYL)-5-(3-HYDROXY-3-METHYLBUTYL)-1-METHYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]ETHENONE | LILLY CO ELI (US) | 2023-09-13 | — | — | EP | claimed |
| US-6495243-B1 | Recording substrates for ink jet printing | XEROX CORPORATION | 2002-12-17 | — | — | US | claimed |
| US-6464773-B1 | Toluene sulfonic acid swelling of perylene pigments | SUN CHEMICAL CORPORATION | 2002-10-15 | — | — | US | claimed |
| WO-2002048267-A2 | TOLUENE SULFONIC ACID SWELLING OF PERYLENE PIGMENTS | CIBA SPECIALTY CHEMICALS HOLDING INC. (US) | 2002-06-20 | — | — | WO | claimed |
| US-5756832-A | REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL | BRISTOL-MYERS SQUIBB CO. (US) | 1998-05-26 | — | — | US | claimed |
| EP-0419076-B1 | Process for the synthesis of soluble, condensed hydridosilicon resins containing low levels of silanol | DOW CORNING (US) | 1995-06-21 | — | — | EP | claimed |
| US-5043397-A | Reacting polyphenylene ether with secondary amine and Bronsted acid | GENERAL ELECTRIC COMPANY (US) | 1991-08-27 | — | — | US | claimed |
| US-5010159-A | Polymerizing a di- or trihalosilane using an arylsulfonate acid hydrate in a hydrocarbon solvent; separating the immiscible layers and recovering | DOW CORNING CORPORATION (US) | 1991-04-23 | — | — | US | claimed |
| EP-0419076-A1 | Process for the synthesis of soluble, condensed hydridosilicon resins containing low levels of silanol | DOW CORNING CORPORATION (US) | 1991-03-27 | — | — | EP | claimed |
| EP-0305860-A1 | Polyphenylene ether amine salts, flame retardant extrudate of blends thereof and method of making | GENERAL ELECTRIC COMPANY (US) | 1989-03-08 | — | — | EP | claimed |
| US-4429112-A | Process of delaying cure of curable resin composition containing cyanate ester compound with benzene sulfonic acid compound | MITSUBISHI GAS CHEMICAL CO., INC. (JP) | 1984-01-31 | — | — | US | claimed |