Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858288 | 0.87 | PTGS2 (0.54) | THRATHRBCYP1A2CYP2C19NPBWR1 | |
| SCHEMBL7050847 | 0.83 | THRB (0.54) | THRATHRB | |
| SCHEMBL7116014 | 0.83 | THRA (0.40) | MEN1KMT2AMAPTTHRATHRB | |
| SCHEMBL7116655 | 0.82 | THRB (0.47) | MEN1KMT2ATHRATHRBCYP1A2 | |
| SCHEMBL4007061 | 0.78 | MEN1 (0.54) | TDP1L3MBTL1RAB9AMEN1KMT2A | |
| SCHEMBL8745429 | 0.76 | THRB (0.48) | THRATHRBPTGS2ALDH1A1TSHR | |
| SCHEMBL5964846 | 0.75 | THRA (0.48) | THRATHRBCYP1A2PTGS2PTGS1 | |
| SCHEMBL7050577 | 0.75 | FOLH1 (0.50) | TDP1KMT2ACYP3A4PTGS2PTGS1 | |
| SCHEMBL7112160 | 0.74 | BACE1 (0.52) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL3925861 | 0.74 | THRA (0.37) | MAPTTHRATHRBNPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |