Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.44 |
| ▸ | THRA | P10827 | 10/20 | 0.44 |
| ▸ | PCNA | P12004 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116011 | 0.88 | THRA (0.40) | THRBTHRALMNAPOLBHIF1A | |
| SCHEMBL7115993 | 0.82 | L3MBTL1 (0.39) | THRBTHRALMNAHIF1AHPGD | |
| SCHEMBL5279150 | 0.75 | THRA (0.40) | THRBTHRAPOLB | |
| SCHEMBL5862535 | 0.75 | HIF1A (0.50) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL5281913 | 0.74 | THRA (0.59) | THRBTHRA | |
| SCHEMBL7122561 | 0.72 | ACHE (0.41) | LMNAHIF1AHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL7114999 | 0.72 | THRB (0.49) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL5288578 | 0.72 | ERN1 (0.44) | THRBTHRA | |
| SCHEMBL5277949 | 0.71 | THRA (0.43) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL5861511 | 0.69 | THRB (0.52) | THRBTHRAPCNALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |