Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628657 | 0.91 | DNM1 (0.44) | EPHX2DNM1FDPSCA1CA2 | |
| SCHEMBL712720 | 0.86 | — | — | |
| SCHEMBL27203931 | 0.85 | EPHX2 (0.38) | EPHX2CYP3A4ALDH1A1DNM1CA1 | |
| SCHEMBL2528776 | 0.84 | EPHX2 (0.40) | EPHX2CYP3A4DNM1FDPSCA1 | |
| SCHEMBL2759865 | 0.83 | ADRB2 (0.38) | EPHX2CYP3A4ALDH1A1DNM1ADRB2 | |
| SCHEMBL11229962 | 0.83 | EPHX2 (0.40) | EPHX2CYP3A4ALDH1A1DNM1ADRB2 | |
| SCHEMBL17743229 | 0.83 | ADRB2 (0.38) | EPHX2CYP3A4ALDH1A1DNM1ADRB2 | |
| SCHEMBL20204695 | 0.83 | ADRB2 (0.38) | EPHX2CYP3A4ALDH1A1DNM1ADRB2 | |
| SCHEMBL2525957 | 0.83 | EPHX2 (0.42) | EPHX2DNM1FDPSCA1CA2 | |
| SCHEMBL16599773 | 0.83 | FAAH (0.39) | EPHX2ALDH1A1DNM1FDPSCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2237774-B1 | THE USE OF 6-HALOGENO-(1,2,4)-TRIAZOLO-(1,5-a)-PYRIMIDINE COMPOUNDS FOR COMBATING PESTS IN AND ON ANIMALS | MERIAL LTD (US) | 2016-06-22 | — | — | EP | disclosed |
| US-9133209-B2 | Insecticidal 4-amino-thieno[2,3-D]-pyrimidine compounds and methods of their use | MERIAL, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2459569-B1 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | MERIAL INC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-9045465-B1 | 3-heterocyclyl-substituted benzoyl derivatives | BASF SE (DE) | 2015-06-02 | — | — | US | disclosed |
| EP-1662877-B1 | 6-HALOGENO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINES FOR COMBATING ANIMAL PESTS | MERIAL LTD (US) | 2014-12-17 | — | — | EP | disclosed |
| US-8664235-B2 | 6-Halogeno-[1,2,4]triazolo[1,5-a]pyrimidines for combating animal pests | MERIAL LIMITED (US) | 2014-03-04 | — | — | US | disclosed |
| US-20120252667-A1 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | MERIAL, INC. | 2012-10-04 | — | — | US | disclosed |
| US-8252925-B2 | Method for the production of 3-phenyl(thio)uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-08-28 | — | — | US | disclosed |
| EP-2459569-A1 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Merial Limited (US) | 2012-06-06 | — | — | EP | disclosed |
| US-8124818-B2 | Method for the production of 3-phenyl(thio) uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-02-28 | — | — | US | disclosed |
| US-5733850-A | HERBICIDES, DESICCANTS OR DEFOLIANTS OF PLANTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-31 | — | — | US | disclosed |
| US-5705707-A | REACTING 1,3-BUTADIENE WITH ALCOHOL; ISOMERIZATION USING TRANSITION METAL CATALYST; HYDROGENATION, HYDROLYSIS | BASF AKTIENGESELLSCHAFT (DE) | 1998-01-06 | — | — | US | disclosed |
| EP-0802905-A1 | SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997035845-A1 | SUBSTITUTED 1-METHYL-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-02 | — | — | WO | disclosed |
| WO-1997001543-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-01-16 | — | — | WO | disclosed |
| WO-1996021645-A1 | SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-18 | — | — | WO | disclosed |
| US-4532239-A | N-phenoxypropanol-N'-pyridazinyl ethylendiamines as β-receptor blockers | CASSELLA AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| EP-0054946-B1 | BASIC SUBSTITUTED PYRIDAZINES, THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1984-08-15 | — | — | EP | disclosed |
| EP-0054946-A1 | Basic substituted pyridazines, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4216314-A | CARDIOSELECTIVE B-ADRENOLYTIC AGENTS, ANTIARRHYTHMIC AGENTS AND HYPOTENSIVE AGENTS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DE) | 1980-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252667-A1 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | P2RX2, P2RX5, P2RX1 | EPHX2 208/4885CYP3A4 2126/4885ALDH1A1 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.