Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412669 | 0.91 | ALDH1A1 (0.48) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL4296349 | 0.85 | ADRB2 (0.47) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL7128071 | 0.83 | KMT2A (0.76) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10413494 | 0.83 | ALDH1A1 (0.45) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10412625 | 0.81 | KMT2A (0.48) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10824134 | 0.81 | HSD17B10 (0.63) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL8041564 | 0.79 | POLB (0.69) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL6687806 | 0.79 | LMNA (0.67) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL29823822 | 0.79 | POLB (0.69) | HPGDALDH1A1KDM4EHSD17B10KMT2A | |
| SCHEMBL10575415 | 0.79 | KMT2A (0.67) | HPGDALDH1A1KDM4EHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |
| US-4945160-A | Preparation of certain 7-substituted quinolones | WARNER-LAMBERT COMPANY (US) | 1990-07-31 | — | — | US | disclosed |