Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766040 | 0.87 | ALDH1A1 (0.53) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8767384 | 0.86 | NR1H4 (0.45) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7123134 | 0.85 | HMGCR (0.44) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8766589 | 0.81 | GAA (0.47) | GAAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8766964 | 0.80 | ALDH1A1 (0.48) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8766734 | 0.75 | ESRRG (0.41) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8616827 | 0.75 | GAA (0.47) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8766658 | 0.74 | MEN1 (0.46) | GAAMEN1KMT2ALMNARECQL | |
| SCHEMBL8767353 | 0.74 | MEN1 (0.49) | GAAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8766760 | 0.73 | MEN1 (0.45) | GAAMEN1KMT2ALMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |