Beclomethasone Dipropionate

SCHEMBL9954979

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Beclomethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.72

▸	CYP3A4	P08684	8/20	0.72

▸	PGR	P06401	6/20	0.72

▸	USP2	O75604	6/20	0.72

▸	HIF1A	Q16665	4/20	0.72

▸	NR1I2	O75469	3/20	0.72

▸	MAPT	P10636	3/20	0.72

▸	ADORA3	P0DMS8	2/20	0.72

▸	CNR1	P21554	2/20	0.72

▸	DRD2	P14416	1/20	0.72

▸	OPRD1	P41143	1/20	0.72

▸	AR	P10275	1/20	0.72

▸	CHRM1	P11229	1/20	0.72

▸	TBXA2R	P21731	1/20	0.72

▸	LMNA	P02545	5/20	0.68

▸	NPSR1	Q6W5P4	3/20	0.64

▸	MLNR	O43193	1/20	0.64

▸	ABCB11	O95342	1/20	0.64

▸	CYP3A5	P20815	1/20	0.64

▸	PPARG	P37231	1/20	0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Betamethasone Dipropionate SCHEMBL3048282	0.96	NR3C1 (0.79)	CYP3A4NR3C1PGRUSP2HIF1A
Beclomethasone Dipropionate SCHEMBL4461051	0.90	NR3C1 (0.90)	CYP3A4NR3C1PGRUSP2HIF1A
Betamethasone Dipropionate SCHEMBL7120868	0.89	NR3C1 (0.68)	CYP3A4NR3C1PGRUSP2HIF1A
Beclomethasone Dipropionate SCHEMBL28089907	0.88	CYP3A4 (0.80)	CYP3A4NR3C1PGRUSP2HIF1A
Clobetasol Propionate SCHEMBL1561443	0.87	CYP3A4 (0.72)	CYP3A4NR3C1PGRUSP2HIF1A
Amcinonide SCHEMBL8420886	0.85	CYP3A4 (0.80)	CYP3A4NR3C1PGRUSP2HIF1A
Beclomethasone Dipropionate SCHEMBL3930412	0.85	CYP3A4 (0.97)	CYP3A4NR3C1PGRUSP2HIF1A
Beclomethasone Dipropionate SCHEMBL10493593	0.85	CYP3A4 (1.00)	CYP3A4NR3C1PGRUSP2HIF1A
Betamethasone Dipropionate SCHEMBL10013893	0.85	NR3C1 (1.00)	CYP3A4NR3C1PGRUSP2HIF1A
Betamethasone Dipropionate SCHEMBL9768468	0.85	NR3C1 (1.00)	CYP3A4NR3C1PGRUSP2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2655416-A1	ANTI-IL-18 ANTIBODIES AND THEIR USES	Medimmune Limited (GB)	2013-10-30	—	—	EP	disclosed
WO-2012085015-A9	ANTI-IL-18 ANTIBODIES AND THEIR USES	MEDIMMUNE LIMITED (GB)	2013-06-27	—	—	WO	disclosed
WO-2012085015-A1	ANTI-IL-18 ANTIBODIES AND THEIR USES	MEDIMMUNE LIMITED (GB)	2012-06-28	—	—	WO	disclosed