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Clobetasol Propionate

Clobetasol Propionate

SCHEMBL1561443

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Clobetasol Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 5/20 0.72
▸ CYP3A4 P08684 7/20 0.72
▸ LMNA P02545 6/20 0.72
▸ PGR P06401 5/20 0.72
▸ USP2 O75604 3/20 0.72
▸ NR1I2 O75469 3/20 0.72
▸ CYP2C9 P11712 3/20 0.72
▸ MAPT P10636 2/20 0.72
▸ MLNR O43193 1/20 0.72
▸ ABCB11 O95342 1/20 0.72
▸ CYP3A5 P20815 1/20 0.72
▸ PPARG P37231 1/20 0.72
▸ SMN1; SMN2 Q16637 1/20 0.72
▸ NPSR1 Q6W5P4 1/20 0.72
▸ CYP2D6 P10635 1/20 0.72
▸ HIF1A Q16665 5/20 0.69
▸ ADORA3 P0DMS8 1/20 0.62
▸ DRD2 P14416 1/20 0.62
▸ OPRD1 P41143 1/20 0.62
▸ MEN1 O00255 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betamethasone Dipropionate SCHEMBL3048282 0.89 NR3C1 (0.79) CYP3A4LMNANR3C1PGRUSP2
Triamcinolone Acetonide SCHEMBL1446089 0.88 HIF1A (0.89) CYP3A4LMNANR3C1PGRNR1I2
Triamcinolone Acetonide SCHEMBL1561091 0.88 HIF1A (0.89) CYP3A4LMNANR3C1PGRNR1I2
Beclomethasone Dipropionate SCHEMBL9954979 0.87 CYP3A4 (0.72) CYP3A4LMNANR3C1PGRUSP2
Triamcinolone Acetonide SCHEMBL8780600 0.86 HIF1A (0.87) CYP3A4LMNANR3C1PGRNR1I2
Triamcinolone Acetonide SCHEMBL28103100 0.86 CYP3A4 (0.87) CYP3A4LMNANR3C1PGRNR1I2
Clobetasol Propionate SCHEMBL3997 0.85 PGR (1.00) CYP3A4LMNANR3C1PGRUSP2
Clobetasol Propionate SCHEMBL445257 0.85 PGR (1.00) CYP3A4LMNANR3C1PGRUSP2
Clobetasol Propionate SCHEMBL5577908 0.85 PGR (1.00) CYP3A4LMNANR3C1PGRUSP2
Clobetasol Propionate SCHEMBL11052078 0.85 PGR (1.00) CYP3A4LMNANR3C1PGRUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2303227-A2 CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS Otonomy, Inc. (US) 2011-04-06 — — EP disclosed
WO-2009139924-A2 CONTROLLED RELEASE CORTICOSTEROID COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2009-11-19 — — WO disclosed
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