Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.51 |
| ▸ | THRA | P10827 | 4/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742868 | 0.86 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL5859386 | 0.81 | FFAR1 (0.64) | THRBTHRAFFAR1CA1CA2 | |
| SCHEMBL3923780 | 0.79 | THRA (0.55) | THRBTHRAGAA | |
| SCHEMBL5393176 | 0.78 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL7114974 | 0.78 | THRB (0.45) | THRBTHRARORCMAPT | |
| SCHEMBL7122312 | 0.76 | RNF4 (0.47) | THRBTHRARORC | |
| SCHEMBL20236189 | 0.75 | HPGD (0.59) | FFAR1CA1CA2HIF1AFFAR4 | |
| SCHEMBL7122037 | 0.75 | FFAR1 (0.43) | THRBFFAR1CA1CA2BCHE | |
| SCHEMBL3914044 | 0.75 | THRA (0.50) | THRBTHRAGAAMAPT | |
| SCHEMBL5388207 | 0.74 | THRB (0.49) | THRBTHRAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |