Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.68 |
| ▸ | TPMT | P51580 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SELL | P14151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SELP | P16109 | 1/20 | 0.46 |
| ▸ | FUT4 | P22083 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431790 | 0.85 | TTR (0.58) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL1114408 | 0.81 | TTR (1.00) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL5560892 | 0.81 | TTR (0.65) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL1071876 | 0.79 | TTR (0.62) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL28408655 | 0.79 | TTR (0.44) | TTRTPMTCA1CA2ALDH1A1 | |
| SCHEMBL865991 | 0.79 | TTR (0.62) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL4847370 | 0.79 | TTR (0.62) | TTRTPMTCA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL11330913 | 0.77 | TTR (0.60) | TTRTPMTCA12CA1CA2 | |
| SCHEMBL10756347 | 0.77 | CASP6 (0.55) | TTRTPMTKDM4EALDH1A1LMNA | |
| SCHEMBL11818428 | 0.76 | APEX1 (0.41) | TTRTPMTCA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230176481-A1 | FILM-FORMING COMPOSITION | NISSAN CHEMICAL CORPORATION (JP) | 2023-06-08 | — | — | US | disclosed |
| EP-3458047-B1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOME DYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION | INST NAT SANTE RECH MED (FR) | 2022-08-03 | — | — | EP | disclosed |
| US-11364219-B2 | Methods and pharmaceutical compositions for treating microbiome dysregulations associated with circadian clock disruption | INSERM (INSTITUT NATION DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (FR) | 2022-06-21 | — | — | US | disclosed |
| CN-109641881-B | 1-tetrahydropyranyl carbonyl-2, 3-dihydro-1H-indole compounds for use in the treatment of cancer | 伊莱利利公司 | 2022-01-07 | — | — | CN | disclosed |
| US-10759786-B2 | 1-tetrahydropyranylcarbonyl-2,3-dihydro-1H-indole compounds for treating cancer | ELI LILLY AND COMPANY (US) | 2020-09-01 | — | — | US | disclosed |
| EP-3468965-B1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | LILLY CO ELI (US) | 2020-04-29 | — | — | EP | disclosed |
| US-20190161477-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-IH-INDOLE COMPOUNDS FOR TREATING CANCER | ELI LILLY AND COMPANY | 2019-05-30 | — | — | US | disclosed |
| EP-3468965-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | Eli Lilly and Company (US) | 2019-04-17 | — | — | EP | disclosed |
| CN-109641881-A | 1- THP trtrahydropyranyl carbonyl -2,3- dihydro -1H- benzazolyl compounds for treating cancer | 伊莱利利公司 | 2019-04-16 | — | — | CN | disclosed |
| US-9872853-B2 | 2,3-dihydro-1H-indole compounds | ELI LILLY AND COMPANY (US) | 2018-01-23 | — | — | US | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2001023347-A1 | NOVEL AROMATIC COMPOUNDS | NOVO NORDISK A/S (DK) | 2001-04-05 | — | — | WO | disclosed |
| EP-0977723-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYARENECARBOXYLIC ACIDS | Finetech Ltd (IL) | 2000-02-09 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| WO-1998047853-A1 | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYARENECARBOXYLIC ACIDS | FINETECH LTD. (IL) | 1998-10-29 | — | — | WO | disclosed |
| EP-0111608-B1 | PSEUDOTROPYL HALOGENO-BENZOATES AND THEIR USE IN MIGRAINE TREATMENT | MERRELL TORAUDE ET COMPAGNIE (FR) | 1987-03-11 | — | — | EP | disclosed |
| US-4486441-A | PROPHYLAXIS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1984-12-04 | — | — | US | disclosed |
| US-4469820-A | Polyurethane prepared from a polyoxyalkylene containing an oxidation inhibiting amount of a benzoic acid salt | BASF WYANDOTTE CORPORATION (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0111608-A1 | Pseudotropyl halogeno-benzoates and their use in migraine treatment | MERRELL TORAUDE ET COMPAGNIE (FR) | 1984-06-27 | — | — | EP | disclosed |
| US-4426300-A | Oxidation stable polyoxyalkylenes containing salts of benzoic acid derivatives | BASF WYANDOTTE CORPORATION (US) | 1984-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190161477-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-IH-INDOLE COMPOUNDS FOR TREATING CANCER | MCL1, IDO1, GLI1 | TTR 3531/4885TPMT 1347/4885CA12 704/4885 |
| US-10759786-B2 | 1-tetrahydropyranylcarbonyl-2,3-dihydro-1H-indole compounds for treating cancer | MCL1, FOXM1, IDO1 | TTR 3658/4885TPMT 842/4885CA12 846/4885 |
| US-11364219-B2 | Methods and pharmaceutical compositions for treating microbiome dysregulations associated with circadian clock disruption | PER2, CRY1, CRY2 | TTR 4318/4885TPMT 1503/4885CA12 1930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.