SCHEMBL5560892

SCHEMBL5560892

O=C(O)c1cc(Br)c(C(=O)O)c(Br)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.65
TPMT P51580 4/20 0.48
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
TP53 P04637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
CA3 P07451 1/20 0.44
MAPT P10636 1/20 0.44
SELL P14151 1/20 0.44
HPGD P15428 1/20 0.44
SELP P16109 1/20 0.44
FUT4 P22083 1/20 0.44
CA4 P22748 1/20 0.44
CA6 P23280 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6059478 0.86 TTR (0.56) TTRTPMTCA12CA1CA2
SCHEMBL8380478 0.84 TPMT (0.56) TTRTPMTCA12CA1CA2
SCHEMBL8380493 0.84 TTR (0.54) TTRTPMTCA12CA1CA2
SCHEMBL7122207 0.81 TTR (0.68) TTRTPMTCA12CA1CA2
SCHEMBL1884074 0.81 AKR1C3 (0.54) TTRCA12CA1CA2CA7
SCHEMBL901061 0.79 CYP3A4 (0.46) TTRTPMTCA12CA1CA2
SCHEMBL1114408 0.79 TTR (1.00) TTRTPMTCA12CA1CA2
SCHEMBL2895332 0.78 CASP6 (0.53) TTRTPMTCA1CA2ALDH1A1
SCHEMBL11336146 0.77 TPMT (0.48) TTRTPMTKDM4EALDH1A1MAPT
SCHEMBL900864 0.77 MAPT (0.48) TTRCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119221151-B Preparation method of high-modulus low-dielectric-constant bromine element modified PBO fiber 山东非金属材料研究所 2025-02-18 CN claimed
CN-119221151-A Preparation method of high-modulus low-dielectric-constant bromine element modified PBO fiber 山东非金属材料研究所 2024-12-31 CN claimed
CN-119221151-B Preparation method of high-modulus low-dielectric-constant bromine element modified PBO fiber 山东非金属材料研究所 2025-02-18 CN disclosed
CN-119221151-A Preparation method of high-modulus low-dielectric-constant bromine element modified PBO fiber 山东非金属材料研究所 2024-12-31 CN disclosed
EP-1363874-B1 TRYPTASE INHIBITORS ALTANA PHARMA AG (DE) 2007-06-06 EP disclosed
US-7101911-B2 Tryptase inhibitors ALTANA PHARMA AG (DE) 2006-09-05 US disclosed
US-20040087791-A1 Bis(substituted propynyl)-substituted benzenes, pyridines, pyrimidines, pyrazines, pyridines, furans and pyrroles; e.g., 3,5-bis-(3-(4-aminomethylbenzylaminocarbonyloxy)prop-1-ynyl)--1 -hydroxymethylbenzene ALTANA PHARMA AG (DE) 2004-05-06 US disclosed
EP-1363874-A2 TRYPTASE INHIBITORS ALTANA Pharma AG (DE) 2003-11-26 EP disclosed
WO-2002066420-A2 TRYPTASE INHIBITORS ALTANA PHARMA AG (DE) 2002-08-29 WO disclosed
EP-0741122-B1 Process for preparing aromatic compounds through decarboxylation of aromatic carboxylic acids CLARIANT GMBH (DE) 1999-08-25 EP disclosed
US-5739388-A Process for the preparation of aromatic compounds by decarboxylation of aromatic carboxylic acids HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-14 US disclosed
CN-1138023-A Process for preparation of aromatic compounds by decarboxylation of aromatic carboxylic acids HOECHST AG (DE) 1996-12-18 CN disclosed
EP-0741122-A1 Process for preparing aromatic compounds through decarboxylation of aromatic carboxylic acids HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040087791-A1 Bis(substituted propynyl)-substituted benzenes, pyridines, pyrimidines, pyrazines, pyridines, furans and pyrroles; e.g., 3,5-bis-(3-(4-aminomethylbenzylaminocarbonyloxy)prop-1-ynyl)--1 -hydroxymethylbenzene TPSB2, TPSAB1, TPSG1 TTR 1671/4885TPMT 197/4885CA12 3649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.