SCHEMBL712228

SCHEMBL712228

C[Si](C)(C)C#Cc1ccc(C#Cc2ccc(F)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 12/20 0.46
FFAR1 O14842 1/20 0.39
TRPV3 Q8NET8 1/20 0.35
APP P05067 1/20 0.35
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3348361 0.98 GRM5 (0.43) GRM5FFAR1TRPV3APPACHE
SCHEMBL1306505 0.88 APP (0.41) GRM5APP
SCHEMBL1306384 0.85 GABRA1 (0.38) GRM5APP
SCHEMBL3603052 0.83 LTA4H (0.50) FFAR1APP
SCHEMBL10300106 0.80 GRM5 (0.50) GRM5FFAR1APPACHE
SCHEMBL7717366 0.80 GRM5 (0.50) GRM5FFAR1APPACHE
SCHEMBL718949 0.80 GRM5 (0.50) GRM5FFAR1APPACHE
SCHEMBL716385 0.79 GRM5 (0.54) GRM5FFAR1ACHE
SCHEMBL712499 0.79 APP (0.57) GRM5FFAR1APP
SCHEMBL2854252 0.78 CYP1A1 (0.44) GRM5APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8703388-B2 Optical data storage media GENERAL ELECTRIC COMPANY (US) 2014-04-22 US disclosed
EP-2290408-B1 Compositions, optical data storage media and methods for using the optical data storage media GEN ELECTRIC (US) 2012-08-15 EP disclosed
US-20120163145-A1 OPTICAL DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY (US) 2012-06-28 US disclosed
US-8124299-B2 Methods for using optical data storage media GENERAL ELECTRIC COMPANY (US) 2012-02-28 US disclosed
US-20110053054-A1 COMPOSITIONS, OPTICAL DATA STORAGE MEDIA AND METHODS FOR USING THE OPTICAL DATA STORAGE MEDIA GENERAL ELECTRIC COMPANY (US) 2011-03-03 US disclosed
EP-2290408-A1 Compositions, optical data storage media and methods for using the optical data storage media General Electric Company (US) 2011-03-02 EP disclosed