Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MDH2 | P40926 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219226 | 0.91 | TRPM8 (0.70) | PKMTRPM8PPARGMEN1KMT2A | |
| SCHEMBL6664147 | 0.89 | ALDH1A1 (0.60) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 | |
| SCHEMBL4473938 | 0.86 | ALDH1A1 (0.65) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 | |
| SCHEMBL9950019 | 0.84 | ALDH1A1 (0.62) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 | |
| SCHEMBL8171524 | 0.84 | PKM (0.61) | PKMALDH1A1SMN1; SMN2PPARGMEN1 | |
| SCHEMBL2811774 | 0.82 | ALDH1A1 (0.66) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 | |
| SCHEMBL11747866 | 0.81 | TRPM8 (0.67) | TRPM8PPARGMEN1KMT2ALTA4H | |
| SCHEMBL28745968 | 0.80 | ALDH1A1 (0.58) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 | |
| SCHEMBL24815324 | 0.80 | PKM (0.56) | PKMALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4486238 | 0.80 | ALDH1A1 (0.64) | TRPM8ALDH1A1SMN1; SMN2HPGDMDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | PKM 2067/4885TRPM8 4661/4885ALDH1A1 1836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.