Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 6/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14855516 | 0.82 | L3MBTL1 (0.47) | KEAP1NFE2L2L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL7117168 | 0.79 | NR1I2 (0.40) | L3MBTL1TSHRHTTNR1I2 | |
| SCHEMBL1409649 | 0.79 | SMN1; SMN2 (0.63) | KEAP1NFE2L2L3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL7118481 | 0.75 | MCL1 (0.44) | L3MBTL1TSHRHTTNR1I2 | |
| SCHEMBL7922299 | 0.72 | L3MBTL1 (0.45) | L3MBTL1SMN1; SMN2TSHRNR1I2 | |
| SCHEMBL3366459 | 0.72 | KEAP1 (0.86) | KEAP1NFE2L2PPARGTSHR | |
| SCHEMBL7119808 | 0.71 | KIF11 (0.42) | L3MBTL1TSHRHTT | |
| SCHEMBL340532 | 0.70 | MEN1 (0.42) | KEAP1NFE2L2L3MBTL1 | |
| SCHEMBL8818175 | 0.69 | CA2 (0.40) | — | |
| SCHEMBL7119429 | 0.69 | CNR2 (0.46) | L3MBTL1SMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |