Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168627 | 0.99 | PKM (0.40) | PKMMAPTTDP1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL6165783 | 0.79 | DNM1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL7125169 | 0.78 | DNM1 (0.31) | — | |
| SCHEMBL2928084 | 0.78 | DNM1 (0.33) | — | |
| SCHEMBL6168001 | 0.78 | PKM (0.44) | PKMMAPTTDP1CYP1A2POLB | |
| SCHEMBL8780365 | 0.74 | PKM (0.53) | PKMMAPTTDP1CYP1A2POLB | |
| SCHEMBL27540293 | 0.74 | PKM (0.49) | PKMMAPTTDP1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL7112027 | 0.73 | PKM (0.51) | PKMMAPTTDP1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL7126153 | 0.73 | MAPT (0.36) | PKMMAPTTDP1CYP1A2POLB | |
| SCHEMBL6168164 | 0.72 | ALDH1A1 (0.53) | MAPTPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660046-B1 | Cationic oxidation bases, their use of dyeing keratin fibres, dyeing compositions and dyeing methods | L'OREAL S.A. (FR) | 2003-12-09 | — | — | US | disclosed |