Sugi Predict

Sugi Predict / Compounds / SCHEMBL712594

SCHEMBL712594

SCHEMBL712594

NS(=O)(=O)NC(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 4/20 0.58
▸ CA12 O43570 3/20 0.58
▸ CA9 Q16790 3/20 0.58
▸ HDAC3 O15379 1/20 0.58
▸ IDO1 P14902 1/20 0.58
▸ ALOX15 P16050 1/20 0.58
▸ HDAC1 Q13547 1/20 0.58
▸ HDAC7 Q8WUI4 1/20 0.58
▸ HDAC2 Q92769 1/20 0.58
▸ HSD17B10 Q99714 1/20 0.58
▸ HDAC8 Q9BY41 1/20 0.58
▸ HDAC6 Q9UBN7 1/20 0.58
▸ NCOR2 Q9Y618 1/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ MEN1 O00255 1/20 0.58
▸ LMNA P02545 1/20 0.58
▸ MAOA P21397 1/20 0.56
▸ GAA P10253 2/20 0.54
▸ CA2 P00918 4/20 0.53
▸ FLT1 P17948 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7107771 0.98 KMT2A (0.56) CA1CA12CA9HDAC3IDO1
SCHEMBL5819670 0.84 CA12 (0.65) CA1CA12CA9HDAC3IDO1
SCHEMBL974471 0.81 KMT2A (0.56) CA1CA12CA9HDAC3IDO1
SCHEMBL3729389 0.80 CA12 (0.60) CA1CA12CA9HDAC3IDO1
SCHEMBL29765489 0.79 HDAC1 (0.61) CA1CA12CA9HDAC1HDAC6
SCHEMBL17806411 0.79 SMN1; SMN2 (0.51) CA1CA12CA9HDAC1HSD17B10
SCHEMBL5372882 0.78 HDAC3 (0.58) CA1CA12CA9HDAC3IDO1
SCHEMBL1750909 0.78 CA12 (0.58) CA1CA12CA9HDAC3IDO1
SCHEMBL6884496 0.78 CA12 (0.58) CA1CA12CA9HDAC3IDO1
SCHEMBL364110 0.78 HDAC3 (0.58) CA1CA12CA9HDAC3IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110204491-A A kind of synthetic method of chirality 3,4- dihydro-isoquinoline ketone compound 台州学院 2019-09-06 — — CN claimed
CN-111868042-B Herbicidal 3-phenylisoxazoline-5-carboxamides of cyclopentylcarboxylic acid derivatives 拜耳公司 2023-12-05 — — CN disclosed
CN-110204491-A A kind of synthetic method of chirality 3,4- dihydro-isoquinoline ketone compound 台州学院 2019-09-06 — — CN disclosed
CN-110204491-A A kind of synthetic method of chirality 3,4- dihydro-isoquinoline ketone compound 台州学院 2019-09-06 — — CN disclosed
CN-104045644-B The manufacture method and metal phthalocyanine compound of metal phthalocyanine compound 富士胶片株式会社 2018-01-16 — — CN disclosed
US-9284295-B2 Tetrahydrobenzothiophene compound ASTELLAS PHARMA INC. (JP) 2016-03-15 — — US disclosed
EP-2537829-B1 Aminobenzoylsulfonamides and their preparation BASF SE (DE) 2016-03-02 — — EP disclosed
US-20150291514-A1 N-Aminosulfonyl Benzamides PFIZER LIMTED (GB) 2015-10-15 — — US disclosed
EP-2565190-B1 TETRAHYDROBENZOTHIOPHENE COMPOUND ASTELLAS PHARMA INC (JP) 2015-06-03 — — EP disclosed
US-20140329802-A1 TETRAHYDROBENZOTHIOPHENE COMPOUND ASTELLAS PHARMA INC. (JP) 2014-11-06 — — US disclosed
US-20060293520-A1 Mehtod for producing 3-phenyl(thio)uracils and 3-phenyldithiouracils BASF AKTIENGESELLSCHAFT (DE) 2006-12-28 — — US disclosed
EP-1692115-A1 METHOD FOR PRODUCING 3-PHENYL(THIO)URACILS AND 3-PHENYLDITHIOURACILS BASF AKTIENGESELLSCHAFT (DE) 2006-08-23 — — EP disclosed
US-20060004220-A1 Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their Preparation BASF AKTIENGESELLSCHAFT (DE) 2006-01-05 — — US disclosed
CN-1717388-A Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation BASF AG (DE) 2006-01-04 — — CN disclosed
EP-1560810-A1 BIFUNCTIONAL PHENYLISO(THIO)CYANATES; METHOD AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF BASF AKTIENGESELLSCHAFT (DE) 2005-08-10 — — EP disclosed
WO-2005054208-A1 METHOD FOR PRODUCING 3-PHENYL(THIO)URACILS AND 3-PHENYLDITHIOURACILS BASF AKTIENGESELLSCHAFT (DE) 2005-06-16 — — WO disclosed
CN-1514824-A Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents — 2004-07-21 — — CN disclosed
WO-2004039768-A1 BIFUNCTIONAL PHENYLISO(THIO)CYANATES; METHOD AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF BASF AKTIENGESELLSCHAFT (DE) 2004-05-13 — — WO disclosed
US-4499303-A Antihyperlipidemic N-benzoylsulfamates, N-benzylsulfamates and benzylsulfonamides RESEARCH CORPORATION (US) 1985-02-12 — — US disclosed
US-4287255-A HAVING A RELEASE SURFACE AND AN ADHESIVE LAYER CONTAINING A PHOTOPOLYMERIZABLE COMPOUND AND A CURED POLYMER STRIP AVERY INTERNATIONAL CORPORATION (US) 1981-09-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060293520-A1 Mehtod for producing 3-phenyl(thio)uracils and 3-phenyldithiouracils HPRT1, TH, METTL3 CA1 2593/4885CA12 4335/4885CA9 2722/4885
US-20140329802-A1 TETRAHYDROBENZOTHIOPHENE COMPOUND SLC34A2, SLC34A1, SLC10A2 CA1 2988/4885CA12 3612/4885CA9 1860/4885
US-20150291514-A1 N-Aminosulfonyl Benzamides SCN7A, SCN2B, SCN1B CA1 2481/4885CA12 3766/4885CA9 2416/4885
US-20060004220-A1 Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their Preparation TST, TMT1A, IDO1 CA1 822/4885CA12 1732/4885CA9 345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.