Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7063906 | 0.82 | HTR6 (0.31) | — | |
| Hydrochloric Acid SCHEMBL30724640 | 0.75 | MEN1 (0.31) | MEN1POLBKMT2AATM | |
| Hydrochloric Acid SCHEMBL8733904 | 0.75 | MEN1 (0.31) | MEN1POLBKMT2AATM | |
| Hydrochloric Acid SCHEMBL7129602 | 0.73 | PDK2 (0.33) | PDK2LMNA | |
| SCHEMBL8517920 | 0.73 | PDK2 (0.32) | PDK2LMNAMEN1POLBKMT2A | |
| SCHEMBL7132981 | 0.72 | PDK2 (0.32) | PDK2LMNAMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL30533389 | 0.72 | HTR2A (0.39) | LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8408379 | 0.70 | MEN1 (0.33) | MEN1POLBKMT2AATM | |
| Hydrochloric Acid SCHEMBL7716227 | 0.70 | HTR6 (0.31) | — | |
| Hydrochloric Acid SCHEMBL8561313 | 0.70 | HTR6 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530908-B2 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM NV (NL) | 2003-06-04 | — | — | EP | disclosed |
| EP-0530908-B1 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM NV (NL) | 1999-04-21 | — | — | EP | disclosed |
| EP-0530908-A1 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM N.V. (NL) | 1993-03-10 | — | — | EP | disclosed |