Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL16794556 | 1.00 | — | — | |
| SCHEMBL7117036 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL639818 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL673192 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL150921 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL16816923 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL673816 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL3965868 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL673190 | 0.95 | ADRB2 (0.42) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 | |
| Zinc Ion SCHEMBL29067893 | 0.95 | CYP3A4 (0.37) | CYP3A4ADRB2ADRB1ADRB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785247-B1 | REFRIGERATOR OIL COMPOSITION | IDEMITSU KOSAN CO (JP) | 2003-11-19 | — | — | EP | claimed |
| US-5858266-A | CONTAINING A HYDROFLUOROCARBON, A PHOSPHOROUS COMPOUND AND AN OXYGEN-CONTAINING ORGANIC COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 1999-01-12 | — | — | US | claimed |
| EP-0785247-A1 | REFRIGERATOR OIL COMPOSITION | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1997-07-23 | — | — | EP | claimed |
| EP-0785247-B1 | REFRIGERATOR OIL COMPOSITION | IDEMITSU KOSAN CO (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-5997761-A | Refrigerating machine oil composition | IDEMITSU KOSAN CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| US-5858266-A | CONTAINING A HYDROFLUOROCARBON, A PHOSPHOROUS COMPOUND AND AN OXYGEN-CONTAINING ORGANIC COMPOUND | IDEMITSU KOSAN CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0785247-A1 | REFRIGERATOR OIL COMPOSITION | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1997-07-23 | — | — | EP | disclosed |