Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 4/20 | 0.50 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22442361 | 0.88 | TTR (0.52) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL19029500 | 0.84 | MAPT (0.57) | NPC1RAB9AHPGDSMN1; SMN2MAPT | |
| SCHEMBL11119157 | 0.81 | RAB9A (0.68) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL29387974 | 0.80 | RAB9A (0.52) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL30041235 | 0.79 | TDP1 (0.54) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL701884 | 0.79 | TDP1 (0.54) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL9305022 | 0.79 | NPC1 (0.46) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL7243392 | 0.78 | GAA (0.64) | HPGDCYP1A2CYP2C9CYP2C19GFER | |
| SCHEMBL9307864 | 0.77 | NPC1 (0.52) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL6790090 | 0.77 | TDP1 (0.47) | NPC1RAB9AHPGDSMN1; SMN2MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660858-B2 | Made by reacting a benzoxazole with a leaving group at the 2 position and a diamine of given formula | LION BIOSCIENCE AG (DE) | 2003-12-09 | — | — | US | disclosed |
| US-20020161028-A1 | 2-aminobenzoxazole derivatives and combinatorial libraries thereof | LION BIOSCIENCE, AG (DE) | 2002-10-31 | — | — | US | disclosed |
| WO-2002079753-A2 | 2-AMINOBENZOXAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161028-A1 | 2-aminobenzoxazole derivatives and combinatorial libraries thereof | BCAT2, IL4I1, BCAT1 | NPC1 4800/4885RAB9A 3050/4885HPGD 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.