SCHEMBL71277

SCHEMBL71277

CC(C)(C)OC(=O)N1CC(OCCCO)C1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.51
PRMT5 O14744 2/20 0.41
WDR77 Q9BQA1 2/20 0.41
USP2 O75604 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NAMPT P43490 1/20 0.38
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
HPGD P15428 1/20 0.37
PDE4B Q07343 1/20 0.35
RECQL P46063 1/20 0.35
EPHX1 P07099 1/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
GPR119 Q8TDV5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28959326 0.95 NR1H2 (0.50) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL20129035 0.94 NR1H2 (0.47) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL2384096 0.90 NR1H2 (0.54) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL20128966 0.90 NR1H2 (0.46) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL20129254 0.88 NR1H2 (0.47) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL28684525 0.88 PRMT5 (0.46) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL20129179 0.88 NR1H2 (0.48) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL22464948 0.86 NR1H2 (0.47) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL26048944 0.86 NR1H2 (0.47) NR1H2PRMT5WDR77USP2SMN1; SMN2
SCHEMBL14714638 0.86 NR1H2 (0.49) NR1H2PRMT5WDR77USP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912699-B2 Tau-protein targeting compounds and associated ARVINAS OPERATIONS, INC. (US) 2024-02-27 US disclosed
US-11912699-B2 Tau-protein targeting compounds and associated ARVINAS OPERATIONS, INC. (US) 2024-02-27 US disclosed
US-20220380376-A1 Nitrogen Oxide-Donating PDE-5 and/or PDE-6 Inhibitor Compounds ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-12-01 US disclosed
US-20220356185-A1 MERTK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2022-11-10 US disclosed
EP-4058457-A2 NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS Ildong Pharmaceutical Co., Ltd. (KR) 2022-09-21 EP disclosed
US-20220153746-A1 NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-05-19 US disclosed
WO-2022096930-A2 NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-05-12 WO disclosed
WO-2021094830-A2 NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS ILDONG PHARMACEUTICAL CO., LTD. (KR) 2021-05-20 WO disclosed
EP-3728251-A1 BIFUNCTIONAL INHIBITORS WITH EGFR HAVING A E3 UBIQUITIN LIGASE MOIETY F. Hoffmann-La Roche AG (CH) 2020-10-28 EP disclosed
US-20200308171-A1 BIFUNCTIONAL INHIBITORS WITH EGFR HAVING A E3 UBIQUITIN LIGASE MOIETY HOFFMANN-LA ROCHE INC. (US) 2020-10-01 US disclosed
US-20200308171-A1 BIFUNCTIONAL INHIBITORS WITH EGFR HAVING A E3 UBIQUITIN LIGASE MOIETY HOFFMANN-LA ROCHE INC. (US) 2020-10-01 US disclosed
CN-111491933-A EGFR bifunctional inhibitors with E3 ubiquitin ligase moiety 豪夫迈·罗氏有限公司 2020-08-04 CN disclosed
US-20180125821-A1 TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2018-05-10 US disclosed
US-20180125821-A1 TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2018-05-10 US disclosed
EP-1961750-B1 VLA-4 INHIBITORY DRUG DAIICHI SANKYO CO LTD (JP) 2013-09-18 EP disclosed
US-20130065882-A1 VLA-4 inhibitory drug MACHINAGA NOBUO (JP) 2013-03-14 US disclosed
US-20120157437-A1 VLA-4 INHIBITORY DRUG DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-06-21 US disclosed
US-8129366-B2 VLA-4 inhibitory drug DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-03-06 US disclosed
US-20090233901-A1 VLA-4 INHIBITORY DRUG DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-09-17 US disclosed
EP-1961750-A1 VLA-4 INHIBITORY DRUG Daiichi Sankyo Company, Limited (JP) 2008-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220380376-A1 Nitrogen Oxide-Donating PDE-5 and/or PDE-6 Inhibitor Compounds PDE6G, PRKG1, PRKG2 NR1H2 3828/4885PRMT5 49/4885WDR77 4691/4885
US-11912699-B2 Tau-protein targeting compounds and associated MAPT, VHL, CRBN NR1H2 3409/4885PRMT5 584/4885WDR77 1631/4885
US-20200308171-A1 BIFUNCTIONAL INHIBITORS WITH EGFR HAVING A E3 UBIQUITIN LIGASE MOIETY EGFR, ERBB2, MDM2 NR1H2 3483/4885PRMT5 1504/4885WDR77 603/4885
US-20120157437-A1 VLA-4 INHIBITORY DRUG VCAM1, ITGB4, ITGA4 NR1H2 231/4885PRMT5 2785/4885WDR77 3497/4885
US-20130065882-A1 VLA-4 inhibitory drug VCAM1, ITGB4, ITGA4 NR1H2 234/4885PRMT5 2809/4885WDR77 3714/4885
US-20180125821-A1 TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE CRBN, VHL, UBQLN2 NR1H2 3751/4885PRMT5 547/4885WDR77 1688/4885
US-20220153746-A1 NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF PDE6G, PRKG1, PDE6D NR1H2 3680/4885PRMT5 97/4885WDR77 4752/4885
US-20090233901-A1 VLA-4 INHIBITORY DRUG VCAM1, ITGB4, ITGA4 NR1H2 447/4885PRMT5 3194/4885WDR77 3252/4885
US-20220356185-A1 MERTK DEGRADERS AND USES THEREOF MERTK, ITK, CRKL NR1H2 2643/4885PRMT5 1469/4885WDR77 1923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.