Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8611255 | 0.87 | ALOX5 (0.43) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL7120195 | 0.85 | HMGCR (0.43) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8766614 | 0.84 | GAA (0.49) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8612757 | 0.84 | HMGCR (0.42) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8767384 | 0.80 | NR1H4 (0.45) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8766961 | 0.80 | GAA (0.39) | PTGS2PTGS1LMNAALDH1A1MEN1 | |
| SCHEMBL7129122 | 0.80 | HMGCR (0.38) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8766028 | 0.79 | LMNA (0.40) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8766469 | 0.77 | LMNA (0.38) | ALOX5PTGS2PTGS1LMNAALDH1A1 | |
| SCHEMBL8766637 | 0.75 | CA1 (0.46) | ALOX5LMNAALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |