Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RGS4 | P49798 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3420455 | 0.81 | EGLN3 (0.46) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL29476087 | 0.81 | PDE4A (0.38) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL3415785 | 0.76 | EGLN3 (0.44) | MEN1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL19267071 | 0.72 | POLB (0.54) | MEN1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL11534161 | 0.71 | LMNA (0.48) | MEN1KMT2ASMN1; SMN2KDM4EPOLB | |
| SCHEMBL838929 | 0.71 | RGS4 (0.58) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL16116321 | 0.70 | ALDH1A1 (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL22344830 | 0.69 | APEX1 (0.55) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL3758300 | 0.69 | APEX1 (0.55) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL30976969 | 0.69 | KDM4E (0.51) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003037262-A2 | NOVEL ANIT-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-08 | — | — | WO | disclosed |