Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074643 | 0.83 | MAPT (0.53) | MAPTMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL2013684 | 0.82 | SMN1; SMN2 (0.60) | MAPTMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL9725384 | 0.80 | ALDH1A1 (0.56) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL10576590 | 0.79 | LMNA (0.68) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL111539 | 0.79 | KAT2B (0.59) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4309629 | 0.79 | MAPT (0.62) | MAPTMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL762553 | 0.79 | SMN1; SMN2 (0.60) | MAPTMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL10580319 | 0.79 | MAPT (0.58) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL29392855 | 0.79 | KAT2B (0.59) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1286500 | 0.78 | MAPT (0.60) | MAPTMEN1KMT2AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216582-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | NIKOLAIDES NICHOLAS (US) | 2003-11-20 | — | — | US | disclosed |
| US-20030087943-A1 | 2-phencycarbamoyl-benzimidazoles | NIKOLAIDES NICHOLAS (US) | 2003-05-08 | — | — | US | disclosed |
| EP-1263737-A1 | 2-PHENYLCARBAMOYL-BENZIMIDAZOLES | THE PROCTER & GAMBLE COMPANY (US) | 2002-12-11 | — | — | EP | disclosed |
| EP-1263736-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | THE PROCTER & GAMBLE COMPANY (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001058878-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | THE PROCTER & GAMBLE COMPANY (US) | 2001-08-16 | — | — | WO | disclosed |
| WO-2001058879-A1 | 2-PHENYLCARBAMOYL-BENZIMIDAZOLES | THE PROCTER & GAMBLE COMPANY (US) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216582-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | CBR3, BAK1, CBR1 | MAPT 4871/4885MEN1 4881/4885KMT2A 2874/4885 |
| US-20030087943-A1 | 2-phencycarbamoyl-benzimidazoles | BRI3BP, CBR3, H1-3 | MAPT 4876/4885MEN1 4856/4885KMT2A 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.