SCHEMBL7129657

SCHEMBL7129657

COC(=O)c1ccc(CSc2ccc(F)cc2)s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
KMT2A Q03164 1/20 0.48
MRGPRX4 Q96LA9 1/20 0.41
LMNA P02545 3/20 0.41
NPSR1 Q6W5P4 2/20 0.41
PPARG P37231 1/20 0.41
NCOA2 Q15596 1/20 0.41
NCOA1 Q15788 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41
L3MBTL1 Q9Y468 5/20 0.40
HPGD P15428 3/20 0.40
MAPK1 P28482 2/20 0.40
TSHR P16473 1/20 0.40
ATM Q13315 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
MAPT P10636 5/20 0.39
KDM4E B2RXH2 2/20 0.39
POLB P06746 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6825954 0.87 L3MBTL1 (0.51) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL6829218 0.86 KMT2A (0.48) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL6829671 0.86 KMT2A (0.54) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL6828829 0.77 ALDH1A1 (0.45) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL29130678 0.77 LMNA (0.49) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL16678438 0.76 ALDH1A1 (0.44) ALDH1A1KMT2ALMNAL3MBTL1HPGD
SCHEMBL6829550 0.76 MRGPRX4 (0.54) ALDH1A1KMT2AMRGPRX4LMNANPSR1
SCHEMBL7164014 0.75 KMT2A (0.56) ALDH1A1KMT2ALMNAL3MBTL1HPGD
SCHEMBL11392272 0.74 KMT2A (0.55) KMT2AL3MBTL1HPGDNPC1RAB9A
SCHEMBL6922276 0.74 LMNA (0.57) ALDH1A1KMT2AMRGPRX4LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004037808-A1 2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2004-05-06 WO disclosed